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The synthesis of thromboxane A2 from arachidonic acid, which serves as a precursor to TBXA2, is facilitated by the activation of phospholipase A2 (PLA2) and subsequent conversion by cyclooxygenase 1 (COX-1) (167)

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The exact content of free thiol groups and other secondary products of LPO process was calculated based on the predetermined extinction coefficient using the MDA standard

10.3390/jcm6020021 [DOI] [PMC free article] [PubMed] [Google Scholar] 79.Kirkham PA, Barnes PJ

The majority of the reported events occurred in patients who experienced gastrointestinal adverse reactions leading to dehydration such as nausea, vomiting, or diarrhea [see Adverse Reactions (6)]